1Biological Anthropology DepartmentNational Research Centre, Giza, Egypt
2Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt
3Internal Medicine Faculty of Medicine, Al-Azhar University- Girls
4Medical Department Medical Research DivisionNational Research Centre, Giza, Egypt
5Medical Biochemistry Department Medical Research DivisionNational Research Centre, Giza, Egypt
*Corresponding Author E-mail: moushiraz@yahoo.com
Online published on 25 August, 2021.
Chemerin has been newly defined to be released from mature adipocytes and the chemerin concentrations in human serum augmented with obesity. There is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. The aim of this study is to expound the prospective role of chemerin the in inflammation. Also, investigate relation between chemerin and serum lipid, glucose, body fat percentage, and metabolic parameters in obese and lean women with IR. Lymphocytes and neutrophils play a major role in inflammation and comprise the first line of defense against infection. The ratio of absolute neutrophil count to lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), determined as is a novel inflammatory biomarker utilized as a prognostic factor in numerous diseases
This study was designed to investigate serum chemerin, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 50 obese women with IR and 50 lean healthy women.
Obese group had significant higher levels of serum chemerin, NLR, hsCRP levels and metabolic parameters than lean one. Chemerin also correlated positively with NLR inflammatory marker and body mass index (BMI). Neutrophil-to-lymphocyte ratio was related to pro-inflammatory
The present study elucidates that chemerin levels are concomitant with obesity and IR and could play a role in the inflammation, having key aspects of metabolic syndrome.
Inflammation, Metabolic parameters, Insulin resistance
