Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 7

In vitro antiviral activity of Pinus merkusii (pinaceae) stem bark and cone against dengue virus type-2 (denv-2)

  • Author:
  • Arif Nur Muhammad Ansori1, Amaq Fadholly1, Annise Proboningrat1, Suhailah Hayaza2, Raden Joko Kuncoroningrat Susilo2, Sin War Naw3, Gabrielle Ann Villar Posa4, Yuhanis Firza Yusrizal5, Mada Triandala Sibero6, Teguh Hari Sucipto7,*, Soegeng Soegijanto7
  • Total Page Count: 4
  • Page Number: 3705 to 3708

1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

2Doctoral Program in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia

3Department of Chemistry, Myitkyina University, Myitkyina, Myanmar

4School of Environmental Science and Management, University of the Philippines Los Banos, Los Banos, Philippines

5Management and Science University, Shah Alam, Malaysia

6Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, Indonesia

7Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia

*Corresponding Author E-mail: teguhharisucipto@staf.unair.ac.id

Online published on 25 August, 2021.

Abstract

Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with ICs0= 140.63 μg/mL and 73.78 μg/mL, CCs0= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.

Keywords

Antiviral, Dengue, Pinus merkusii, Vero Cell