Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 8

Antihyperglycemic activity of Ficus carica leaves extracts on Streptozotocin induced diabetic rats

  • Author:
  • Tathagata Roy1*, Susanta Paul1, Victor Roy Chowdhury1, Arijit Das2, Srikanta Chandra3, Avik Das4, Abhishek Jana5, Muniraj Bhattacharya5, Nibir Ghosh5
  • Total Page Count: 6
  • Page Number: 4151 to 4156

1Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109

2Assistant Professor, Bharat Technology, Uluberia, Howrah

3Assistant Professor, Jakir Hossain Institute of Pharmacy, Murshidabad

4Assistant Professor, Gupta College of Technological Sciences, Asansol

5Department of Pharmaceutical Technology, JIS University, Kolkata700109

*Corresponding Author E-mail: troy@jisuniversity.ac.in

Online published on 1 October, 2021.

Abstract

Antihyperglycemic activity of leave extracts of Ficus carica was evaluated on STZ induced diabetic rats. Diabetes was induced in albino Wistar rats of either sex by intraperitoneal (60mg/kg b.w.) of STZ, freshly dissolved in citrate buffer (0.01 M, pH 4.5). Ficus carica leave extract in different solution (viz. petroleum ether, ethyloacetate, methanol and aqueous) were administered to diabetic rats for 9 days. The effect of extracts on blood glucose and body weight was studies on day 1st and 9th. The study showed that the ethyl acetate, methanolic and aqueous extract of Ficus sarmentosa leaves reduced blood glucose level and body weight significantly. This may justify the use of ficus species as ethanomedical medicine for treatment of diabetes mellitus.

Keywords

Streptozotocin (STZ), Antihyperglycemic, Intraperitonial, Diabetes mellitus