1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia
2Study Program of Fishery Pathology Management Techniques, Marine and Fisheries Polytechnic, Sidoarjo, 61253, Indonesia
3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah, Purwokerto, 53182, Indonesia
4Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia
5Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia
6Research Center for Vaccine Technology and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia
7Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, 60286, Indonesia
*Corresponding Author E-mail: annise.drh@gmail.com
Online Published on 22 February, 2022.
Cancer is a significant global health problem today and responsible for most deaths after cardiovascular diseases. One of the conventional modalities for cancer treatment is chemotherapy. However, it has many side effects and complications. Therefore, the search for novel drug candidates from natural ingredients that are more effective and have minimal side effects is critical. This study is aimed to determine the cytotoxic effect of Allium cepa L. extract on human cervical cancer cells. The cytotoxicity test procedure was performed using MTT assay against HeLa cells. The result revealed that Allium cepa L. ethanolic extract has a weak cytotoxic effect on HeLa cells with IC50 of 900.88 μg/ml. Further research into Allium cepa L. is required to isolate and identify its components and determine their potential as new agents against HeLa cells.
Common onion, Cervical cancer, HeLa cell lines, Cytotoxicity assay
