Medicated Lacquer Formulation for the Treatment of Nail Psoriasis

Nail psoriasis to cure would like a protracted period of treatment and relapse is common. The common Side effects of oral anti-psoriatic drugs when used for the treatment of nail Psoriasis include liver toxicity, while treatment for nail psoriasis includes monthly injection of corticosteroids into the nail folds. Topical therapy, using nail lacquer as a delivery vehicle, targets the drug to its site of action, thus, drug interactions and adverse events arising from systemic drug exposure can be avoided. The transungual drug delivery system is related to the drug delivery over the nail, which is hard because of the presence of a keratin network into the nail. So, this review mainly concentrates on drug delivery over nail by using medicated nail lacquer formulations. The drug delivery via the nail plate is done due to the association of psoriasis. Generally used medications are clobetasol, tacalcito, tazarotene, urea, calcipotriene. There are several factors such as the molecular size of the drug, hydrophilicity, and lipophilicity of diffusing molecule, nature of the vehicle, formulation effect, which affects the delivery of drugs through the nail plate. This present review also mainly focuses on the delivery of drugs using formulation in the form of the medicated-psoriatic nail lacquer.