A study on anti-inflammatory activity of stem bark extract of Holoptelea integrifolia

Holoptelea integrifolia has been used for a long time in traditional medicine to cure inflammatory pain. The goal of the current research was to consider the anti-inflammatory activity and phytochemicals study of both the extracts of the stem bark of Holoptelea integrifolia.

Anti-inflammatory potential was figure out in Carrageenan and Histamine models at 200 mg/kg doses. Apart from this, we have evaluated parameters like paw edema body weight, locomotor activity, hematological, biochemical assessment, etc.

Qualitative chemical test investigation of both the extracts of H. integrifolia stem bark acknowledge the presence of proteins, amino acids, alkaloids, glycosides, tannins, and flavenoids. The 200 mg/kg, p.o dose of the extract showed remarked (P < 0.05) dose-dependent inhibition of edema formation. Both the ethanolic extract (200 mg/kg, b. w) and aqueous extract (200 mg/kg, b. w) of H. integrifolia stem bark showed remarked anti-inflammatory properties in comparison to reference drug Ibuprofen. In the Carrageenan model, the ethanolic extract has good anti-inflammatory activity than the aqueous extract. So, the ethanolic extract of stem bark of H. integrifolia is used to combat inflammation alone or with other conventional anti-inflammatory agents to treat different inflammatory disorders.

Taken together, these results support the traditional use of Holoptelea integrifolia as a potent anti-inflammatory agent that may be proposed for the treatment of inflammatory pain.