1Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225
2Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
3Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
4Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B
5Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
6Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
7Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
8Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109
*Corresponding Author E-mail: troy@jisuniversity.ac.in
Online Published on 13 June, 2022.
Ulcerative colitis (UC) is a recurrent ulceroinflammatory disease that is mainly restricted to colonic mucosa with variable colonic architecture distortion. Different types of drugs are used for management of UC namely Salfasalazine, Balsalazide, Mesalamine etc. However, they are associated with different types of adverse effects such as nausea, vomiting, skin rash, headache. Hence, we narrowed in on Colocasia esculenta and its available in India, Bangladesh, Pakistan. In our present study the anticolitic effects Colocasia esculenta in treatment the TNBS induced model for UC in mice were examined.
Male mice, 7 weeks of age, are selected. They are divided into various categories: Negative control groups treated with normal saline solution, positive control group treated with TNBS5%, standard group treated with Balsalazide 4mg/kg & TNBS 5%, Test(1) group treated with Colocasia esculenta 100mg/kg, Test(2) group treated with Colocasia esculenta 150 mg/kg, Test(3) group treated with Colocasia esculenta 250 mg/kg then we were performed various parameters such as DAI, Oxidative damage assessment, MPO Assessment.
The results have been showed that Colocasia esculenta has significant activity against TNBS (5%) induced colitis when compared to the experimental control, with near normalization of colon architecture. Tissue oxidative stress was reduced with significant improvement in tissue levels of MDA &GSH. Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed.
It is concluded that Colocasia esculenta(250mg/kg) has got potent activity against TNBS (5%) induced ulcerative colitis (UC) due to its anti-inflammatory& antioxidant properties.
Ulcerative colitis, Anti-inflammatory, Antioxidant, Colocasia esculenta, Myeloperoxidase
