Apigenin: Review of mechanisms of action as antimalarial

Apigenin is a natural compound that is present in a number of plants such as celery, parsley, grapes, chamomile, onions, maize, tea, sugar, and sprouts belonging to the flavone subclass of flavonoid. Like vitamins, anti-inflammatory medications, vasodilators, anticoagulation, antidiabetes, anticancer, antimalarial drugs, apigenin has many pharmacological functions. The main therapeutic agent for malarial disease is apigenin, based on in vitro, in vivo, and silico research. The purpose of the review is to describe the mechanism of apigenin as an antimalarial agent. Apigenin has antimalarial mechanisms that are confirmed to induce ABCC1 transporters, inhibit protein kinase (Pf RIO-2 kinase) (right open reading frame-2 protein kinase), and act as an antioxidant.