The future prospective: Potential magnesium and calcium for detracting side effect cisplatin

Cancer has been caused by more death globally and is associated with magnesium and calcium intake with some cancers. Some studies are shown as a protective agent against chemotherapy-induced nephrotoxicity and neurotoxicity. Despite magnesium and calcium are the opposite in inflammation, reabsorption regulation, and other physiological processes. However, it is important to maintain the balance between magnesium and calcium related to the micronutrients’ physiological functions. One of the cancer drugs can lead to hypomagnesemia and hypocalcemia electrolytes such as cisplatin. The purpose of this article is to review the cisplatin mechanism in electrolyte disorder and the association between potential magnesium and calcium for therapy of some cancer.