Studying the anti-cancer activity of resveratrol 1,3,4-thiadiazol derivatives

The used Resveratrol-Thiadiazol derivatives (A, B, C) were prepared and characterized by 1H-13C NMR and FT-IR spectroscopies. This study used two cell lines for cytotoxicity testing: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells), The result of anticancer study showed that derivative C had significant selectivity on MCF-7 used in this study even in very low concentration used to evaluate the anticancer activity while derivatives A and B showed non-significant selectivity on MCF-7 in low concentration while in high concentration showed small selectivity which may be negligible, this selectivity determined according to the comparison between: MCF-7 (Human Breast Cancer Cells) and WRL-68 (Human Normal Liver Cells).