Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai - 600117, Tamilnadu, India
*Corresponding Author E-mail: komala.sps@velsuniv.ac.in
Online published on 1 March, 2023.
Clofarabine is a second-generation purine nucleoside analogue with antineoplastic activity. The objective of this study was to prepare the Clofarabine nanoparticles loaded as OLEO-ALGINATE-ESTER conjugate, that OLEO-ALGINATE-ESTER conjugate could self-assemble to form nanoparticles when dissolved in water and the sparingly soluble Clofarabine could be entrapped within nanoparticles that stabilizes the Clofarabine in aqueous medium. Clofarabine loaded OLEO-ALGINATE-ESTER nanoparticles (Clofarabine-OLEO-ALGINATE-ESTER Nps) were prepared by simple ultra-sonication method. Meanwhile, the physiochemical characteristics of Clofarabine-OEA-Nps including particle-size and its distribution, zeta potential, drug entrapment efficiency and in-vitro drug release studies were determined. Furthermore, the cytotoxicity and cellular uptake of conjugated nanoparticles in to cancer cell linings were investigated.
Fabrication, Cytotoxic activity, Sodium alginate ester nanoparticles, Clofarabine, Cell linings
