1Institute of Marine Biotechnology, University Malaysia Terengganu, 21030, Kuala Terengganu, Malaysia
2Faculty of Fisheries and Food Science, University Malaysia Terengganu, 21030, Kuala Terengganu, Malaysia
*Corresponding Author E-mail: gul.saba@umt.edu.my, sababiochem@gmail.com
Online published on 1 March, 2023.
The research effort aimed to evaluate the antimicrobial activity of Chitosan derived from Tilapia fish scales. The production of Chitosan achieved by chemical hydrolysis involving demineralization, deproteinization and deacetylation. The antibacterial activities performed against Staphylococcus aureus, Bacillus cereus, Streptococcus agalactiea, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi. The bacteriostatic and bactericidal effect is measured via Minimum Inhibitory Concentrations (MIC) and the Minimum Bactericidal Concentrations (MBC). Chitin yielded 32.74% from 100 grams of dried fish scales in this study, whereas Chitosan yielded 62.13%. Also, the ratio of MBC/MIC determination reveals the bacteriostatic effect of a Chitosan at given concentrations. Therefore, the antibacterial cationic polymer isolated from Tilapia fish scales utilized in various industrial field. The use of derivatization shows a positive role in control drug release systems.
Antibacterial, Biopolymers, Chitosan, MIC, MBC, Biomedicines, Drug delivery, Control release
