1Department of Pharmaceutical Technology, JIS University, Kolkata, West Bengal-700109
2Department of Pharmaceutical Technology, Bharat Pharmaceutical Technology, Amtali, West Tripura- 799130
3Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, MSR Nagar, Bangalore, Karnataka, India - 560054
4Natural Cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, India-799022
5Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, West Bengal-713206, India
*Corresponding Author E-mail: baidyamoushumi@gmail.com
Online published on 3 March, 2023.
Traditional medicine may also cause genetic damage that may increase the possibility of cancer and other diseases. Therefore, it is essential to evaluate the genotoxic testing of Siddha drugs. Therefore, a latest take a look at become performed to evaluate the in vivo genotoxic effects of Sivanar Amirtham in mice using micro nucleus assay. Three different doses of 100, 200, and 400 mg / kg b.w were selected in accordance with OECD guidelines. In a micronucleus test, the administration of one oral Sivanar Amirtham at 100, 200 and 400 mg / kg b.w did no longer increase with the mean amount of micronucleated polychromatic erythrocytes or PCE percentage for both sexes showing non clastogenicity. For this reason it could be concluded, Sivanar Amirtham showed no vast genotoxic impact on the rats in both sexes. Sivanar Amirtham was therefore not carcinogenic and therefore could be used safely.
Genotoxicity, Sivanar Amirtham, Micronucleus, Carcinogenic
