Phytochemical screening and antipyretic activity of Atylosia rugosa

In the present study, the ethanolic extract of Atylosia rugosa was investigated for antipyretic activity in rats by using brewers yeast induced pyrexia. The plant was collected from tirumala hills, dried and powdered, to about 1000gms. This powder was subjected to successive soxhlet extraction using petroleum ether, choloroform, acetone, ethylacetate and ethanol. In this study only ethanolic extract was subjected to antipyretic activity. The study was carried out in healthy wistar albino rats weighing about 150-200g, brewers yeast of 20% suspension of 20ml/kg in normal saline is used for inducing pyrexia for antipyretic activity. The animals were divided into five groups. Group I is treated with 2%v/v Tween80 (10ml/kg), Group II treated with Paracetamol 100mg/kg, Group III, IV, V treated with ethanolic extract of Atylosia rugosa 100mg/kg, 200mg/kg, 400mg/kg body weight respectively. Conclusion: A positive, significant linear relationship between antipyretic activity and the phytocontituents. The extract is rich of phenolic compounds and flavonoids. The present study revealed the significant antipyretic activity of the plant is because of its active metabolites in the plant in the Atylosia rugosa.