1Saras College of Pharmacy, Baghpat, Uttar Pradesh, 250622, India
2Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh247121, India
3Department of Pharmaceutics, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, Uttar Pradesh201206, India
*Corresponding Author E-mail: dineshgupta_008@rediffmail.com
Online published on 14 June, 2022.
Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi's kinetics for drug release.
Lovastatin, Zeta potential, Solid lipid nanoparticles
