Formulation and development of sustained release of cefixime using floating oral In situ gelling system

The present study was planned to prepare Gastro-retentive controlled release of floating in situ gel of Cefixime by using sodium alginate and xanthan gum. The six floating in situ gelling formulations (F1 to F6) were evaluated for visual appearance, pH, gelation, viscosity, buoyancy, drug content, water uptake, gel density, gel strength, drug release and stability. The results of above parameters were found to be satisfactorily. The F6 showed drug release for longer time and it was considered a best formation. The F6 were stable at the selected temperature and humidity when stored for 3 months. The findings it was concluded that the prepared sustained release in situ gel of Cefixime might be safe and effective controlled drug delivery for extended period of time.