Gastroretentive drug delivery system: An overview

Oral route is considered as the most convenient, accepted and safest way for drug delivery, achieving better therapeutic effectiveness by delivery of drug at specific site in controlled manner is getting more attention now a days and GRDDS is one of the novel approaches which prolongs gastric residence time and releases a drug at specific targeted site of stomach for local or systemic effects. This approach is useful for drugs having narrow absorption window in upper part of GI tract. In this review we have discussed various aspects of GRDDS like merits, demerits, physiology of stomach, and potential drug candidate for GRDDS, factors affecting gastric retention, polymers and other materials used in GRDDS, Various approaches for gastric retention and evaluation of GRDDS concisely.