1Assistant Professor, Department of Chemistry, LCIT College of Commerce & Science, Bilaspur, (C.G.), India
2Professor, Department of Chemistry, Dr. C.V. Raman University, Kota-495113, Dist-Bilaspur, (C.G.), India
3Research Scholar, Department of Chemistry, Dr. C.V. Raman University, Kota-495113, Dist-Bilaspur, (C.G.), India
*Corresponding Author E-mail: kaushik.jaishri08@gmail.com
Online published on 20 February, 2023.
The Simple, selective, and expeditious spectrophotometric methods have been developed for the determination of complexation of 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol with metal ions in pharmaceutical field. The method was based on complex formation between the antihypotensive drug and transition metal ions in a basic medium (pH 9.2). The colored complexes were measured at 280 nm wavelength for 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1, 2-diol. The different experimental parameters affecting the development and stability of the colour were carefully studied and optimized. The stability constant of complex were calculated to be Ag(I)-4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 4.34, Pd (II)-4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 5.75 & Cd (II) - 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 3.82 by job's continuous variation method. The stoichiometry of the complexes formed between the antihypotensive drugs and the metal ions was 1:1 M/L ratio. The proposed method was further applied to the determination of drug in pure and dosage forms. The results obtained were in good agreement with those obtained by a reference to UV-Visible Spectrophotometric method.
Complexation, Antihypotensive drug, Stability constant, Job's method, Spectrophotometer
