1Institute of Pharmacy, Bundelkhand University, Kanpur Road, JhansiUP – 284128
2School of Pharmaceutical Sciences, Maharishi University of Information Technology, Lucknow
*Corresponding Author E-mail: bbau27verma@gmail.com
Online Published on 20 February, 2023.
The objective of current study was to formulate and characterize nanolipid carriers of paclitaxel with increased solubility and % release profile of the drug which leads improvement of bioavailability.
It is proposed to incorporate the hydrophobic anticancer drug such as paclitaxel in NLCs to increase the bioavailability and solubility of the therapeutic agent and to assess the developed formulation’s efficacy by in-vitro drug release profile. The main intents of the study are to utilize the various attributes of the proposed biopolymer (glycerol caprate) for the preparation of NLCs to encapsulate paclitaxel. The objectives of the study are to appraise the morphological, physiochemical characteristics of the developed system with their in-vitro performance.
The result of the NLCs characterization was evaluated by Zeta potential, poly dispersity index (PDI), percentage entrapment efficiency, drug loading, solubility and partition co-efficient.
The result concluded stable NLCs formulation with improved solubility and extended in-vitro drug release.
Paclitaxel, NLCs, SEM, Partition co-efficient, In-vitro Drug Release, Bioavailability
