1Dept of Pharmaceutical Science, RDIC - C. U. Shah University, Wadhwan, Gujarat, India
2Dept of Pharmaceutical Chemistry and Quality Assurance - IPCPRC, Dharmaj, Gujarat, India
3Faculty of Pharmacy, Parul Institute of Pharmacy and Research, Faculty of Pharmacy, Parul University, P.O Limda, Vadodra, Gujarat, India
4Dept of Pharmaceutical Analysis and Quality Assurance, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India
5Dept of Pharmaceutics, Sardar Patel College of Pharmacy, At post – Bakrol, Anand, Gujarat, India
*Corresponding Author E-mail: rdumpala64@gmail.com
Online Published on 20 February, 2023.
Aim of the current research work to conduct bio availability of Nicardipine Hydrochloride S-SMEDDS in rats, compare with pure drug and Marketed Formulation. Study is conducted by using Wistar rats. 3-Groups were divided into Set-A Pure Drug, Set B: Marketed formulation, Set C: Optimized formulation, Total 18 healthy rats were selected, 6 in each group with weight of 300±50g Rats were labeled by numbers. Blood samples were collected from Tail vein method at pre-determined time intervals then blood samples were analyzed by validated HPLC method. S-SMEDDS exhibit cmax at 1429.58±107.40ng/mL, tmax at 0.75Hr, AUC(0-t) at 3042.05±333.35 ng. min/ml and t1/2 at 3.49±0.016 hr. AUC and maximum plasma concentration of the S-SMEDDS is higher than pure Nicardipine Hydrochloride drug and marketed formulation it indicates S-SMEDDS produce more bioavailability than Nicardipine Hydrochloride powder.
Rats, Bioavailability, Nicardipine Hydrochloride, S-SMEDDS
