Synthesis, characterization and antimicrobial study of novel substituted curcumin derivatives

Chemically, curcumin is a diaryl heptanoid, belonging to the group of curcuminoids, which are natural phenols responsible for turmeric's yellow color. It is a Keto-enol tautomer, existing in enolic form in organic solvents and in keto form in water. The one pot three component of hydrazide substituted benzaldehyde was used for the synthesis of curcumin derivatives. In this work the synthesis of curcumin derivatives was done using an environmental friendly procedure via Mg-Al-CO₃ hydrotalcites which have been used as efficient catalysts. These catalysts are inexpensive and non-toxic powders. Data of Spectra and other analytical technique supported identification of compound curcumin derivatives. The present work offers many merits such as the reaction conditions were extremely simple, there was operational simplicity, reaction time was short, easy to work up and purification was also easy for the products via simple means of re-crystallization. The antibacterial activity of three compounds B2, B4 and D3 was found to be near to the significant with standard compounds amoxicillin.