1Department of Pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute of Medical Sciences, Deemed To Be University, Karad - 415539, India
2Research Group Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415111, Maharashtra, India
3Department of Pharmacology, Annasaheb Dange College of Pharmacy, Ashta, Maharashtra, India
*Corresponding Author E-mail: amol.shete@rediffmail.com
Online published on 21 February, 2023.
The objectives of present investigation were to prepare and evaluate liquid crystalline gel, study the effect of water concentration on liquid crystalline phases, incorporate antifungal agent and itraconazole (ITZ) co-crystals into liquid crystalline vehicle. Liquid crystalline gel formulations were prepared by using glyceryl mono-oleate GMO, water and other excipients. The prepared gel formulations were evaluated for various parameters like rheological, in vitro drug diffusion and in vivo skin irritation test etc. Differential scanning calorimetric spectra of ITZ loaded gel showed higher transition peak temperature 96.71°C and ITZ loaded co-crystal gel showed 99.2°C and pH 6.8 and 6.5 respectively. Enhanced rate of diffusion was observed when gels were loaded with co-crystals. The prepared liquid crystalline gel formulations containing itraconazole and its co-crystals were found useful in a topical delivery with improvement for in vitro and in vivo performance.
Itraconazole, Liquid Crystals, Co-crystals, Diffusion, Antifungal, Topical
