1Department of Pharmacy, FEAT, Annamalai University, Chidambaram – 608002, Tamilnadu.
2School of Pharmaceutical Sciences, Vel’s Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai – 600117.
*Corresponding Author E-mail: devivarshni@gmail.com
Online Published on 23 February, 2023.
This study determine the consistency of Lamotrigine with various drug formulations using the testing procedures such as differential scanning calorimetry and Fourier Transform Infrared Mass spectrometry.
Possible strong interactions between the drug and excipients affect the molecular nature, stability, and bioavailability of drugs, affecting therapeutic efficacy and protection. To see if there was a connection, the FTIR spectrum and DSC thermograms of raw drug, excipients, or drug-excipient mixtures were evaluated.
The drug had not come into contact with the excipients, according to the facts. Either of the excipients were mostly found to be consistent with the medication and can be used in the production of novel formulations based on the results obtained from DSC and FTIR.
Preformulation, Drug Compatibility, DSC and FTIR
