1Department of Health in Baghdad Rusafa, Kamal Al-Samarrai Hospital, Baghdad, Iraq.
2Department of Pharmacy, Al-Rasheed University College, Baghdad, Iraq.
3Medical Laboratory Techniques Department, Al-Rasheed University College, Baghdad, Iraq.
4Department of Chemistry, Faculty of Science, Cankiri Karatekin University, 18100Cankiri, Turkey.
5Department of Dentistry, Al-Rasheed University College, Baghdad, Iraq.
6College of Technical Engineering, The Islamic University, Najaf, Iraq.
*Corresponding Author E-mail: roaa.hatem@alrasheedcol.edu.iq, rooa.aljibory@gmail.com
Online Published on 23 February, 2023.
The Growth Differentiation Factor -15 (GDF-15) is a member of the transforming growth factor β superfamily. It represents an example of the stress response cytokines. It's mostly found in cardiac myocytes, adipocytes, macrophages, endothelial cells, and vascular endothelial cells, whether they're generated normally or not. GDF-15 levels have increased and are associated with cardiovascular risk.
To investigate the correlation between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) with the level of plasma GDF-15 in a group of hypertensive patients.
A case-control study involved 90 individuals, 60 hypertensive patients (36 on ACE inhibitors and 24 on ARBs) and 30 healthy individuals. Serum GDF-15 was measured and compared statistically between the two groups.
Serum GDF-15 was significantly higher in both groups of hypertensive patients compared to the control group. In addition, there was no significant difference in mean serum GDF-15 concentration between patients treated with ACE inhibitors with those treated with angiotensin II receptor blockers.
GDF-15 increases in hypertensive patients and might be a reasonable marker of cardiovascular disease. Both ACE inhibitors and ARBs are not powerful enough to decrease GDF-15 concentration to that of the control group.
GDF-15, LVH, Hypertension, ARBs, ACE inhibitors
