1Assistant Professor, Department of Pharmaceutical Chemistry, SSR College of Pharmacy, Sayli, Silvassa - 396230, India.
2Assistant Professor, Department of Pharmaceutical Quality Assurance, SSR College of Pharmacy, Sayli, Silvassa - 396230, India.
*Corresponding Author E-mail: parixitprajapati@gmail.com
**chandnichandarana7343@gmail.com
Online Published on 23 February, 2023.
An eco-friendly method for quantification of Omeprazole in Pharmaceutical solid dosage form has been developed using Fourier transform infrared spectrophotometry. The proposed method avoids use of solvents which are commonly used for other methods of quantification e.g. Liquid Chromatography, UV spectrophotometry etc. The developed method has been validated for quantification of Omeprazole in marketed formulation as per ICH Q2 R (1) guidelines. The method is based on Beer-lamberts’ law. For the quantification C-O stretch absorption band at 1204 cm−1 was selected which is typically in the range of 1300 – 1000cm−1 in IR spectrum. The linearity of Omeprazole was obtained in the concentration range of 5 – 30mg/g with R2 value of 0.999. The % recovery was calculated with Intra and Inter day precision study.
FTIR spectrophotometry, Green analytical method, Omeprazole, C-O stretching peak
