Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2022
  • Volume: 15
  • Issue: 8

Schiff bases compounds prepared from Phenyl hydrazine as a starting material were Synthesized, Characterized, and their Biological activity was Investigated

  • Author:
  • Nuha Salman Salih1,*, Widad Ibrahem Yahya1,**, Hutham Mahmood Yousif Al-Labban1,***, Ahmed Abduljabbar Jaloob Aljanaby2,****
  • Total Page Count: 4
  • Page Number: 3595 to 3598

1University of Kufa, Faculty of Science, Department of Chemistry, Iraq.

2University of Kufa, Faculty of Science, Department of Biology, Iraq.

*Corresponding Author E-mail: nuha.rabee@uokufa.edu.iq

**widadi.atyah@uokufa.edu.iq

***huthamm.sadiq@uokufa.edu.iq

****ahmedaj.aljanabi@uokufa.edu.iq

Online Published on 23 February, 2023.

Abstract

Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B, and C). The reactions phases and series were studied using IR spectroscopy and thin layer chromatography (TLC) (ethyl acetate: toluene, 1:4). Three derivate compounds were used as antibacterial activity in this study. The results proved that all derivative compounds provided good inhibition zone against Staphylococcus aureus and pseudomonas aeruginosa especially in concentration 300mg/ml of derivative compound C with diameter inhibition zone 21.433±0.676 and 625.33±0.796 respectively.

Keywords

Phenylhydrazine, Schiff bases, Antibacterial activity, Staphylococcus aureus, Pseudomonas aeruginosa, Iraq