1Biology Education Department Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia
2Department of Medical Laboratory Technology, STIKES Hutama Abdi Husada, Tulungagung, Indonesia
3Professor Nidom Foundation, Surabaya, Indonesia
4Faculty of Biotechnology, University of Surabaya, Surabaya, Indonesia
5School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, Philippines
6College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Qassim, Saudi Arabia
7College of Medicine, Maastricht University, Maastricht, The Netherlands
8Department of Biotechnology, Toraighyrov University, Pavlodar, Kazakhstan
*Corresponding Author E-mail: doraturistaofficial@gmail.com
Online published on 27 February, 2023.
Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Application of alloxan in experimental animals can cause Diabetes mellitus. The secondary metabolites of Etlingera elatior can be used as raw materials for diabetes mellitus drug. This study aims to determine the antidiabetic potential of ethanol extract of Etlingera elatior leaves by in vivo study. A total of 32 rats were divided into 6 groups, namely NC, DC, PC, DE1, DE2, and DE3. The results of data analysis using multivariate ANOVA on blood glucose level data every week showed p(0.000) < (0.05), and the results of data analysis using one way ANOVA on pancreatic β cell count data also showed that p(0.000) < (0.05). Etlingera elatior leaf ethanol extract has antidiabetic activity since it could reduce blood glucose levels and increase the number of pancreatic β beta cells through several mechanisms. The mechanism is triggered by phytochemical compounds contained in the leaf extract of Etlingera elatior.
Alloxan, Diabetes mellitus, Etlingera elatior, Blood glucose level, Pancreatic cells
