1Datta Meghe College of Pharmacy & Technology Management, DMIMS (DU), Wardha
2Sharadchandra Pawar College of Pharmacy, Savitribai Phule Pune University, Otur, Dist Junnar, India
3Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’S NMIMS, Mumbai
*Corresponding Author E-mail: pravinagurjar.pusad@gmail.com
Online published on 27 February, 2023.
The purpose of this study was to prepare pregabalin loaded niosomal dispersion for controlled release of drug and achieve therapeutic effect for longer duration than the available drug delivery.
The niosome carriers were formulated using non-ionic surfactants and cholesterol ratio of 1:1. The effects of non-ionic surfactant and cholesterol on the average particle size and percent entrapment efficiency were studied. Optimization of the formulation was performed by factorial design using Design expert software 11.0.
Based on the solutions provided by the design expert software, the formulation resulted in the particle size of 490 nm and 92.4% EE as compared to the predicted values of 491.02nm for particle size and 90% EE. The optimized niosome carriers appeared as multilamellar vesicles, as evident by a scanning electron microscopy study. Anticonvulsant activity of the niosomal dispersion was determined by Pentylenetetrazol (PTZ) induced convulsions in mice. Pregabalin-loaded niosomal dispersion displayed a sustained and moderate anticonvulsant effect upto 24 h.
Therefore, the present study revealed the possibility of using non-ionic surfactant niosomes as carrier systems for prolonged release of pregabalin.
Niosome, Niosomal dispersion, DOE in niosomal formulation, Pregabalin, PTZ induced convulsion
