Synthesis of novel bioactive compounds of 5-arylidene-2-imino-thiazolidin-4-ones as antimicrobial agents

In this study, a variety of 3,3'-(pyrazine-2,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis[2-imino-5-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one] derivatives have been synthesized with good yields starting by reaction of pyrazine-2,3-dicarboxylic acid and thiosemicarbazide. The resulted compound 2-amino-1,3,4-thiadiazole was treated with chloroacetic acid to give the corresponding chloroacetamide which further refluxed with potassium thiocyanate. The condensation of the product 2-imino-1,3-thiazolidin-4-one with different 5-substitutedpyridine-2-carbaldehyde produced the titled compounds. An agreement for the proposed structures were approved based on the elemental analysis, FT-IR, 1H NMR and 13C NMR spectra. Antimicrobial activity of the newly thiazolidinones have been estimated with powerful results.