1Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, P.O. Box 4030, Jubail, Saudi Arabia
2Vaasudhara College of Pharmacy, Sante Circle, Chintamani Road, Hoskote, 562114, Karnataka, India
3College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Al-Ahsa, Saudi Arabia
4King Abdullah International Medical Research Center, Al-Ahsa, Saudi Arabia
5Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
6Department of Respiratory Care, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, P.O. Box 4030, Jubail, Saudi Arabia
7Department of Respiratory Care, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, KSA
8College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, KSA
9Department of Neuroscience Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia
*Corresponding Author E-mail: jmuthumohamed@gmail.com
Online Published on 10 October, 2023.
The present study was carried out to evaluate the interaction analysis and antiulcerogenic activity of hydroalcoholic leaves extract of Salvia fruticosa leaves against ethanol induced gastric ulceration. Phytochemical and acute toxicity studies were carried out with standard methods. The docking studies performed using the CHARMm algorithm between 6YLU and phytoconstituent. Ulcers are induced in rats by administration of ethanol (1ml/kg, p.o.). One hour prior to ethanol administration, the various groups are treated with Salvia fruticosa extract (250 and 500mg/kg) and standard ranitidine (200mg/kg). A phytochemical study, shows the presence of various phytochemical constituents, while acute toxicity studies found no sign of toxicity. Results of docking studies showed two molecules rosmerinic acid (-54.1556kcal/mol) and stearic acid (-45.8874kcal/mol) showed higher affinity than standard drug. Treatment with extract at dose of 250 and 500mg/kg showed significant reduction in the ulcer score and ulcerative index, when compared to the standard drug Ranitidine.
Salvia fruticosa, Hydroalcoholic extract, Anti-ulcer activity, Docking studies, Interaction analysis
