1Department of Pharmacy Practice, Ramaiah University of Applied Sciences, Bangalore, 560054, India
2Department of Pharmacy Practice, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
3ADR Monitoring Centre, Karpagam Faculty of Medical Sciences and Research, Coimbatore
4Pharmacovigilance Programme of India (NCC-PvPI), Indian Pharmacopoeia Commission, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India
*Corresponding Author E-mail: deepapharmacy@jssuni.edu.in
Online Published on 01 February, 2024.
Lennox gastaut syndrome (LGS) is a childhood onset severe epileptic encephalopathy with multiple seizures types usually refractory to pharmacological management. Despite the availability of various anti-epileptic drugs, children with LGS continue to have seizures. LGS refractory to pharmacological treatment leads to poor prognoses like severe intellectual disability and persisting seizures. Dietary treatment along with anti – epileptics can result in less patient exposure to drugs. In this report, we present a case of 11 years old child of LGS with worsening of intellectual disability. Adapting non pharmacological treatment can reduce the patient exposure to drugs and seizure control. Surgical options are recommended when patient doesn’t respond to anti – epileptic drugs. Corpus callosotomy and vagus nerve stimulation are most recent advances in surgical treatment of LGS. Although more data are needed to confirm efficacy of non pharmacological options, in many cases they resulted in complete reduction of seizure.
Lennox Gastaut Syndrome, Anti – epileptic drugs, Non – pharmacological treatment options
