1Research Scholar, Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301Petaling Jaya, Selangor D. E, Malaysia
2Deputy Vice Chancellor (Research & Innovations), Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301Petaling Jaya, Selangor D. E, Malaysia
3Lecturer, Medical Faculty, University of Baiturrahmah, Jalan Raya By Pass, Aie Pacah, Koto Tangah, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat, 25586, Indonesia
*Corresponding Author E-mail: sandeeppoddar@lincoln.edu.my
Online Published on 01 February, 2024.
Pediococcus acidilactici is one of the lactic acid bacteria that acts as a probiotic isolated from buffalo milk fermentation (Dadiah). Dadiah is a functional food that is rich in lactic acid bacteria and acts as a probiotic. Probiotics have many health benefits for humans and animals, one of which is as a Tumor Necrosis Factor (TNF) expression inhibitor which is able to suppress the physiological response to TNF which is part of the inflammatory response where TNF itself is involved in autoimmune and immune disorders. So with the use of TNF inhibitors from secondary metabolites Pediococcus acidilactici can prevent and treat TNF. This study aims to determine the secondary metabolites of Pediococcus acidilactici to TNF inhibitor and immunomodulator expression by looking at the canonical and isomeric SMILE (simplified molecular-input line-entry system) structures in the Pub Chem database. After conducting bioinformatics analysis to determine the secondary metabolites of Pediococcus acidilactici, the value of TNF inhibitor expression was 0.63 and as an immunomodulator 0.42 meaning that Pediococcus acidilactici isolated from Dadiah from Bukittinggi was able to act as TNF inhibitor and immunomodulator expression.
Probiotics, Dadiah, Immunomodulators, Pediococcus acidilactici, Tumor necrosis factor
