Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2023
  • Volume: 16
  • Issue: 10

Compression of Genetic Expression of Progesterone and Prostaglandin E2 Between PCOS and Non-PCOS Women

  • Author:
  • Sura B. Sharafaldeen1,*, Amoura M. Abou-El-Naga1, Saad S. Al-Dujialy2, Ahmed Badawy3
  • Total Page Count: 5
  • Page Number: 4781 to 4785

1Zoology Department, Mansoura University, Eygpt

2High Institute for Infertility Diagnosis and ART, Al-Nahrain University, Iraq

3College of Medicine, Mansoura University, Egypt

*Corresponding Author E-mail: surabadie113@gmail.com

Online Published on 01 February, 2024.

Abstract

Several hormones may interact with the implantation process by mobilizing several molecular modulators in a spatiotemporal manner. A total of 31 women were selected intentionally, then divided into (16) with polycystic ovarian syndrome and (15) healthy women with male factor, the blood serum samples were analyzed by real-time quantitativepolymerase chain reaction (RT- qPCR) for measurement of the fold of expression for Progesterone (P4) and Prostaglandin (PGE2) in the day of ova pick up (OPU) and after 14 days of embryo transfer (ET) in pregnant and non-pregnant women for PCOS and Non-PCOS groups. The results showed that there were no statically significant differences encountered between non-PCOS andPCOS groups in the expression of progesterone and prostaglandin genes (P 0.7296) and ( P 0.0530) respectively.

1- P4 and COX-2 expression in women PCOS is less common in healthy women than in menopausal women. 2- COX-2 is one of the indicators to consider in the case of blastocyst adhesion to the uterine wall.3-In both the PCOS and non-PCOS groups, there was a small increase in P4 and PGE2 expression on the day of ova collection and after 14 days after embryo transfer.

Keywords

PGE2, Progesterone, COX2