Validated photodiode array based stability indicating RP-HPLC method for simultaneous estimation of cinnarizine and domperidone maleate in tablet dosage form

For the simultaneous measurement of Cinnarizine and Domperidone Maleate in bulk and tablet dosage form, a accurate, reliable, robust, and cost-effective RP-HPLC method is developed. Chromatographic separation was accomplished using a mobile phase of Acetonitrile: 10mM Potassium dihydrogen phosphate (pH 3.0) (70:30% v/v) in an isocratic elution mode at a flow rate of 1mL/min on a Neuclosil C18 (25cm×4.6mm, 5μm) column at a wavelength of 271nm. Acidic, basic, oxidative, thermal, and photolytic stress environments were used to degrade the drugs. Cinnarizine and Domperidone Maleate were found to have linearities of 8-48μg/mL and 7.6-45.6 μg/mL, respectively. For both medicines, a % recovery of 99-101 was discovered. This method was validated as per ICH (Q₂R₁) guideline.