Platelet derived growth factor expression after administration of okra fruit extract on diabetic wistar rats

Increased AGEs in diabetics promote a protracted inflammatory response and macrophage malfunction in growth factor release, one of which being Platelet Derived Growth Factor (PDGF). The disruption of proliferation and angiogenesis is influenced by a reduction in PDGF expression. Okra (Abelmoschus esculentus) fruit extract possesses antioxidant, anti-inflammatory, and anti-diabetic properties. This extract aids in the inflammatory process, macrophage proliferation, and immunomodulatory macrophage roles in the production of growth factors.

The goal of this study was to observed if giving an okra fruit extract to a diabetic Wistar rat will improve the expression of PDGF in the wound healing process following tooth extraction.

24 Wistar rats were divided into 2 groups: Control Group (Streptozotocin-induced), and Treatment Group (Streptozotocin-induced and treated with okra fruit extract 250mg/kgB Woral sonde once a day after extraction). Extraction was performed on the lower jaw left incisor. Four rats from each group were sacrificed on day 3, 5, and 7 after the extraction. To evaluate the number of PDGF expression, the socket on the left lower jaw was cut open and immunohistochemistry was performed.

There was a significant difference between the number of PDGF expressions on the treatment group on day 3 (10.92245±0.80934), day 5 (15.71875±1.31646) day 7(17.71875±1.24506) with control group on day 3(3.71875±1.65004), 5(7.94791± 0.51637), and 7(7.89062±0.61740).

On diabetic Wistar rats, okra fruit extract modulates the increase in PDGF expression in wounds after tooth extraction.