1Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Mayjen Prof. Dr. Moestopo street No 6-8, Surabaya, Indonesia
2Department of Otorhinolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, KubangKerian, Kelantan, Malaysia
*Corresponding Author E-mail: baharudin@usm.my
**elsarosalina.orlhns@gmail.com
Online Published on 07 February, 2024.
Local allergic rhinitis (LAR) is the symptom of allergic rhinitis in which nasal allergen-specific immunoglobulin E(IgE) is detected but has no sensitivity to systemic allergens. The gold standard test is the nasal allergen provocation test (NAPT) which requires a complicated procedure. Specific IgE in nasal mucosa test is the less invasive and easier diagnostic alternative for LAR.
This review aimed to determine the validity of the nasal house dust mite - specific IgE test for LAR patients.
A meta-analysis was conducted in chronic rhinitis patients with negative skin prick test (SPT) and serum IgE.
The research was using PubMed Central, Cochrane library, SAGE journals, and Science Direct were searched until July 29th, 2022. The validity of the nasal HDM - specific IgE test was compared to NAPT.
A total of 413 research articles were selected and five articles were included. The QUADAS-2 assessment showed minimum publication bias. The total sample was 236 patients. Pooled sensitivity 90.00%, I2= 28.95% and p=0.01. Pooled specificity 96.00%, I2= 30.28% and p=0.00. The value of the area under the curve in the SROC curve = 0.9710, statistically significant.
The nasal HDM- specific IgE test is valid for diagnosing patients with LAR.
Local allergic rhinitis, Nasal specific immunoglobulin E test, House dust mites, Nasal allergen provocation test, Chronic respiratory diseases
