Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2023
  • Volume: 16
  • Issue: 12

The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating

  • Author:
  • Ismail Bennani1,2, Ali Cherif Chefchaouni3,4,*, Hajar Benhaddou3, Madiha Chentoufi Alami5, Badreddine Moukafih1,2, Soufiane El Marrakchi1,2, Aicha Fahry3, Yassir El Alaoui3,4, Younes Rahali3,4, Abdeslam El Kartouti1, Youssef Hafidi2, Abdelkader Laatiris3, Nawal Cherkaoui3
  • Total Page Count: 3
  • Page Number: 5912 to 5914

1Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco

2Department of Pharmacy, Hassan II University Hospital of Fez, Morocco

3Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco

4Ibn Sina University Hospital Center, Rabat, Morocco

5Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaâdi University

*Corresponding Author E-mail: chefchaouniali@gmail.com

Online Published on 07 February, 2024.

Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug known for its remarkable therapeutic effects. It can be available in different forms among which are coated and sugar-coated tablets.The objective of this study was to compare the dissolution profile between these two forms. The study was conducted with 5 ibuprofen drugs: 3 generics and one reference drug based on coated tablets, and one drug containing the coated tablets.The parameters used to evaluate and compare the dissolution profiles were the similarity (f2) and difference (f1) factors.The results obtained showed similar dissolution profiles for the two types of coating, with a more significant release for the sugar-coated tabletsduring the first 30 minutes.Dissolution studies are important studies to establish equivalence between generic and brand name drugs, and also to predict the release of the AP.

Keywords

Ibuprofen, Dissolution, Coating, Sugar-coating