Effects of polyphenols on changes in the transport of Ca²⁺ NMDA-receptors under the influence of L-glutamate

Increasing amount of evidence suggests that age-related dysregulation of neuronal Ca²⁺ homeostasis may play a proximal role in the pathogenesis of Alzheimer's disease, as impaired Ca²⁺ can cause synaptic deficits and contribute to the accumulation of Aβ plaques and neurofibrillary tangles.Ca²⁺ disruption is known to be mostly involved in all pathologies of Alzheimer's disease, the use of chemical agents or small molecules specific for Ca²⁺ channels, or the treatment of proteins on the plasma membrane and intracellular organelle membranes for correction is quite possible. Neuronal dysregulation of Ca²⁺ may open up a new approach to the prevention and treatment of Alzheimer's disease. The article shows the possible competition between the polyphenols PC-6, PC-7 and glutamate for the area of regulation of the opening of ion channels of ionotropic NMDA-receptors in the brain of rats.