Development and In-vitro Effectiveness of tooth-gel containing herbal extracts

The aim of the current research was to formulate and evaluate herbal extracts tooth gel of of Emblica officinalis, Terminalia bellirica, Terminalia chebula, Trachycpermum ammi, Embelia ribes and Syzygium aromaticum, which are used for oral hygiene, plaque control, gingivitis, anti-bacterial, astringent and prevent tooth decay. Powders were extracted separately and further evaluated for phytochemical screening which showed presence of phytoconstituents like alkaloids, tannins, flavonoids and carbohydrates. A 2³ factorial design was used to optimize tooth gel using independent variables: concentration of sodium carboxymethyl cellulose (X₁) (2 and 3 %); concentration of Gantrex (X₂) (0 and 1%) and concentration of sodium lauryl sulphate (X₃) (1.5 and 2.5 %) and dependent variables foaming capacity (Y₁) and zone of inhibition (Y₂). Tooth gel was evaluated for color, odor, taste and pH. Gel exhibited good viscosity, extrudability, spreadability and antimicrobial activity. Formulation F5 showed highest foamability (48.2±0.4ml) and zone of inhibition (4.4±0.2cm) with the desirability value 1 (most desirable response) at design space X₁ = 2%, X₂ = 0%, X₃ = 2.5 % and was therefore considered optimize formulation. Formulation was found stable after 3 months of stability studies. Thus, formulated toothgel had better results when compared with marketed formulation. In conclusion, formulated toothgel was considered as helpful to take care of oral hygiene of human being.