1Faculty of Pharmacy, AIMST University, Bedong08100, Kedah, Malaysia
2Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Bedong08100, Kedah, Malaysia
3Faculty of Medicine, AIMST University, Bedong08100, Kedah, Malaysia
4Faculty of Dentistry, AIMST University, Bedong08100, Kedah, Malaysia
*Corresponding Author E-mail: shalini.shanmugavelu@aimst.edu.my, shanmugamshalini37@gmail.com
Online Published on 12 October, 2023.
Pathogenic bacteria based Periimplantitis is a serious concern for the of dental implants failure. Evidences over S. aureus and E. coli to cause periimplantitis, antibacterial potential of Cinnamomum iners and cinnamic acid motivated present study to compare the antibacterial activity of hydrazide derivative of cinnamic acid (HDCA) and Cinnamomum iners leaves extract (CILE) against periimplantitis triggering microbes (PTM). Current study involved synthesis of HDCA and preparation of CILE. The HDCA was characterized using ATR-IR, 1H-NMR and Mass spectrometric data. Both HDCA and CILE were further investigated for their antibacterial activity against PTM that is Escherichia coli and Staphylococcus aureus. Among two, the HDCA exhibited high antibacterial activity when compared with CILE. Based on the results, present study concludes that HDCA possess high antimicrobial potential against PTM and recommends that HDCA should be further investigated to support its clinical significance.
Periimplantitis, Cinnamic acid, Comparison, Extract, Antibacterial
