1Department of Forensic Medicine, Salahaddin Health Directorate, Iraq
2Department of Pharmacology and Toxicology, University of Baghdad, College of Pharmacy, Baghdad, Iraq
*Corresponding Author E-mail: ruyaalialbayaty@gmail.com
Online Published on 16 October, 2023.
Gugglusterone has been reported to provide protection against inflammatory and oxidative reactions of different pathological conditions.
The main object of this research work is to evaluate the renoprotective effects of guggulsterone in the prevention of cisplatin-induced nephrotoxicity in rats via assessment of renal function and histological study.
Rats in this study were split into four groups which comprise a control group, an induction group, a third group receiving low-dose guggulsterone, and a fourth group receiving high-dose guggulsterone.
A single dose of cisplatin drug has jeopardisedrenal physiology that has been demonstrated in histopathology sections and elevation of serum creatinine and urea concentrations. However, concurrent use of Guggulsteronehas provided improved histological findings and significantly (P<0.05) reduced serum creatinine and urea levels compared to the positive control of cisplatin-induced damage.
Guggulsteronehas provided a potentially reasonable protective kidney effect against vitiated insults.
Renoprotection, Cisplatin Toxicity, Guggulsterone, Kidney Biomarker
