Evaluation activity of antimicrobial and antidiabetic the baby fruit of Isem Kembang (Mangifera quadrifida Jack)

Isem Kembang (Mangifera quadrifida Jack) is a native and rare fruit found in Lampung, Indonesia. It is a member of the genus Mangifera, family Anacardiaceae. The objective of this research was to evaluate the capability of antimicrobial and antidiabetic activities for the baby fruit of isem kembang (Mangifera quadrifida Jack). This study was conducted in two steps namely extraction with a maceration method using n-hexane solvent, ethyl acetate and methanol. Furthermore, antimicrobial and antidiabetic were tested with disk diffusion assay method and antidiabetic activity test with α-glucosidase inhibition test. The research revealed Antidiabetic activity of the baby fruit of isem kembang (Mangifera quadrifida Jack) with various extracts increased with increase of concentration level. The antimicrobial activity of an ethyl acetate extract of the baby fruit isem kembang (Mangifera quadrifida Jack) was found to be greater than standard, with an inhibition zone of 28mm against Escherichia coli and 23mm against Bacillus cereus. Antidiabetic activity of The baby fruit of isem kembang (Mangifera quadrifida Jack) with methanol extract had antidiabetic activity with IC₅₀ of 0.04mg/L. The three extracts of baby fruit isem kembang (Mangifera quadrifida Jack) have high potential as antimicrobial and antidiabetic activity.