Stroke and its association with sickle cell disease - A review

Stroke is one of the roots of disabilities and deaths. Generally, strokes are put into two groups (i.e., ischemic stroke or hemorrhagic stroke). Once the flow of blood to the brain is stopped or insufficient, the cells are short of oxygen and nutrients which results in a stroke via the mechanism of neuronal cell death. Signs of stroke might vary, including ace flipping, weakened limbs, speech problem, vision change, body imbalance, misperception, and cognition loss. The burden of stroke not only faces the patient and medical workforce but also family members and the community. People with sickle cell disease might face a stroke in their life due to the interlink between sickle cell disease and stroke. In this review, we discussed stroke, its types, mechanisms of neuronal cell death, the association between stroke and sickle cell disease, and therapeutical interventions. The future direction requires the efforts and contribution of each person to ensure that there are less or no disabilities and/or death which caused by the incidence of stroke.