1Department of Human Genetics, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University)
2Department of Obstetrics and Gynaecology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai-116
4Controller of Examinations, Tamil Nadu Veterinary and Animal Sciences University, Chennai
*Corresponding Author E-mail: balunathan:nandhinibals@gmail.com
***venkip@sriramachandra.edu.in
Online Published on 31 October, 2023.
Endometriosis is a common gynaecological disease, with many theories on the endometriosis pathogenesis in association with the regulation of cell multiplication and neo-angiogenesis.
The current study is a case control estimation of Interleukin 4 and Interleukin 18 in women with endometriosis, compared with that of a control group of healthy women without endometriosis.
Peripheral blood samples were collected from the study groups: 40 women with endometriosis and 40 women without non-endometriosis. Concentration of cytokines, IL-4 and IL-18 were estimated using ELISA method.
Results showed that the concentration of both IL-4 and IL-18 serum were significantly higher in women with endometriosis when compared with women without endometriosis group (p=0.0005).
Cytokines play their specific roles in pathogenesis of endometriosis. IL-4 and IL-18 cytokines could be used as a biomarker for non-invasive test for endometriosis. Further studies are needed with more data to determine their role as a biomarker for endometriosis.
Cytokines, Interleukins, ELISA, Endometriosis
