1Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada, Andhra Pradesh, India
2Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India
*Corresponding Author E-mail: arifashaik2007@gmail.com
Online Published on 31 October, 2023.
Buccal mucoadhesive patches of losartan potassium were formulated using hydroxypropyl methyl cellulose grades - K4M, K15M, K50M and Eudragit L100 polymers by the method of solvent casting. The prepared formulations were characterized for mechanical and physicochemical parameters like thickness, surface pH, uniformity of weight, swelling index, folding endurance, percentage moisture loss, drug content, in vitro dispersion and in vitro residence time. Further, in vitro drug release study was performed with the use of freshly prepared egg membrane as the semi-permeable membrane. The best formulation (F6) exhibited higher percentage of drug release 97.26%±0.41 at the end of 8 h. The sustained release of losartan potassium was found to be attained up to 8 h duration.
Buccal delivery, Mucoadhesive patches, Polyvinyl alcohol, Hydroxypropyl methyl cellulose, Folding endurance
