1Department of Chemistry, Bipin Bihari College, Affiliated To Bundelkhand University, Jhansi-284001, Uttar Pradesh, India
2Department of Chemistry, Indian Institute of Technology, Banaras Hindu University, Varanasi - 221 005, Uttar Pradesh, India
*Corresponding Author E-mail: sbajpai7@gmail.com
Online Published on 31 October, 2023.
Indole based quinoxaline derivatives (2a-f) were synthesized and the therapeutic potential of the synthesized compounds (2a-f) was investigated against Dalton’s Lymphoma (DL) cells. It was observed that treatment of DL cells with quinoxaline derivatives (2a-f) showed significant decrease in cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, the synthesized compounds may be used as potential therapeutic regimen to treat this type of cancer.
Quinoxaline derivatives, Dalton’s lymphoma cells, Viability, Anti-cancer potential, Apoptosis
