Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq
*Corresponding Author E-mail: rehamtaleb@yahoo.com
Online Published on 31 October, 2023.
Drug-induced nephrotoxicity is one of the most common causes of acute kidney injury. Cisplatin is one of the most effective and potent anticancer drugs, induces a reduction in the antioxidant, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drug.
This study was conducted to examine the possible ameliorative activity of Daflon against Cis-induce acute kidney injury.
Animals divided into six groups, group I: received NaCl on a daily; group II: received Cisplatin (7.5mg/kg) single dose; group III: received Daflon mini dose (50mg/kg) for 15 successive days, group IV: received Daflon max dose (100mg/kg/day) for 15 successive days; group V: received Daflon mini dose (50mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, group VI : received Daflon max dose (100mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, Finally, after euthanization of each animal by diethyl ether, the samples were collected for analysis. Serum MDA, Serum GSH and Tumor Necrosis Factor (TNF-α) had been used as an indicator for the protective effect of Daflon.
The results show that administration of Daflon for 15 days had significant protective effect against cisplatin induced nephrotoxicity.
Cisplatin (Cis), Malondialdehyde (MDA), Nephrotoxicity, Reduced glutathione (GSH), Tumor Necrosis Factor (TNF-α)
