The growth of ETV6-NTRK3 harbouring cells was inhibited by Artemisia vulgaris L. crude extract

Artemisia vulgaris L. has a long history of use in traditional medicine for the treatment of a wide range of ailments. Advancements in science and technology established scientific evidence for this medicinal plant. Recent studies have shown that A. vulgaris inhibits the growth of numerous cancer cell lines, including MCF-7, HepG2, Hela, and K-562. To access the potential anti-leukemia activity of A. vulgaris crude methanol extract (MetAV) on the ETV6-NTRK3-carrying cells, the IMS-M2, MO-91, and BaF3-CFS cell lines were co-cultured with MetAV for 48 h before being stained with Trypan Blue to calculate the percentage of viable cells. With IC50 values of 26.98 ± 2.25; 21.85 ± 0.92; and 18.70 ± 1.70 μg/ml for IMS-M2, MO-91, and BaF3-CFS, respectively, the results indicated that MetAV had a significant effect on the examined cells.