1Doctor Program, Faculty of Fisheries and Marine Science, University of Brawijaya, Malang, East Java, Indonesia
3Faculty of Fisheries and Marine Science, Papua University, Manokwari, 98314, West Papua, Indonesia
2Faculty of Fisheries and Marine Science, University of Brawijaya, Malang, East Java, Indonesia
Tambelo reportedly has a positive impact on health. Our study investigates the possible effect of tambelo extract as an anti-inflammatory in mice induced by lipopolysaccharide (LPS) Tambelo phytochemistry from liquid chromatography analysis - high-resolution mass spectrometry (LCMS) coupled with NF-κB protein, docking was carried out to pursue anti-inflammatory properties. Thirty Balb/C mice were randomized into six groups: untreated, LPS, dexamethasone + LPS, and tambelo extract with doses of 100, 150, and 200 mg/kg BW + LPS, respectively. The results of this study indicate that there are four compounds which has a high affinity for the target protein. High CD4+CD25+ expression after treatment with fermented products tambelo (BE) significantly attenuated LPS-induced mice (p<0.05). Our findings show that fermentation tambelo protects against induced LPS by maintaining Tregs. Tambelo may have the potential as a food choice due to its anti-inflammatory properties.
Anti-inflammatory, CD4+CD25+, Tambelo, LCMS, Lipopolysaccharide, LPS
