Comparison of double dose of paracetamol tablets 500mg with one paracetamol tablet 1000mg

Various geometrical shapes of paracetamol tablets are available, which play an important effect on the speed and quantity of drug release and swallow ability. Patients with swallowing disorders experience difficulties taking large dose (1000mg), which may lead to take two smaller tablets 500mg. This study purposes to investigate the impact of doubling dose and different geometrics on drug release, depending on dissolution test and surface area to volume ratio (SA/V). First, all the studied companies were confirmed to the required constitutional specifications. Then, the dimensions of different shapes of tablets and SA/V ratio were calculated by using Solid Works program. Finally, the dissolution test was performed in a medium of phosphate buffer (pH=5.8) for 30 minutes. All tablets were accepted in term of uniformity of content and weight and showed acceptable friability, with suitable hardness and the disintegration time was less than 30 minutes. After half an hour of beginning the dissolution test, over 80% of the paracetamol from all the tablets examined was found to have been released. The release rates were approximately constant for the various shapes of tablets with the same rate of SA/V. Drug release from two tablets of 500mg was faster than that from one tablet of 1000mg, this offers a therapeutic benefit to achieve the analgesic effect more quickly.